Transcription of Pre-eclampsia: pathophysiology and clinical implications
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Pre-eclampsia: pathophysiology and clinical implications
Interactions between senescence of the placenta and a maternal genetic predisposition to cardiovascular and metabolic disease. While often presented as distinct sub-types, in reality the balance between the placental and maternal causations most likely varies among indi-viduals across the spectrum of gestational age at clinical presentation. We discuss the pathophysiology in the light of recent advances of our understanding of the maternal-fetal interactions that take place in the first weeks fol-lowing implantation, and emphasize the importance of the endometrium during the pre- and peri-conceptional periods for pregnancy and selection criteriaA PubMed search (pre- eclampsia OR preeclampsia) AND (placenta OR placental)] at the end of 2018 with no date restrictions yielded 10 611 citations.
same time, major breakthroughs in clinical management were few, and the substantial improvements in maternal death rates from pre-eclampsia/eclampsia were achieved by empirical advances in care, professional education, higher clinical competence, and, more recently, consist - ent application of national guidelines such as in the UK
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