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Primary Biliary Cholangitis: 2018 Practice Guidance from ...

1 Practice Guidance | Hepatology, Vol. 0, No. 0, 2018 Primary Biliary cholangitis : 2018 Practice Guidance from the American Association for the Study of liver DiseasesKeith D. Lindor,1 Christopher L. Bowlus,2 James Boyer,3 Cynthia Levy,4 and Marlyn Mayo5 PreambleThis American Association for the Study of liver Diseases (AASLD) 2018 Practice Guidance on Primary Biliary cholangitis (PBC) is an update of the PBC guidelines published in 2009. The 2018 updated Guidance on PBC includes updates on etiol-ogy and diagnosis, role of imaging, clinical manifesta-tions, and treatment of PBC since 2009. The AASLD 2018 PBC Guidance provides a data-supported approach to screening, diagnosis, and clinical man-agement of patients with PBC.

liver disease in older asymptomatic patients or possi-bly because referrals to subspecialists were made only when patients became symptomatic.(51) diSeaSe progreSSioN Histologic stages have been found to predict sur-vival.(50,52) The rate of histologic progression has

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