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Primary Biliary Cholangitis: 2018 Practice Guidance from ...

1 Practice Guidance | Hepatology, Vol. 0, No. 0, 2018 Primary Biliary cholangitis : 2018 Practice Guidance from the American Association for the Study of Liver DiseasesKeith D. Lindor,1 Christopher L. Bowlus,2 James Boyer,3 Cynthia Levy,4 and Marlyn Mayo5 PreambleThis American Association for the Study of Liver Diseases (AASLD) 2018 Practice Guidance on Primary Biliary cholangitis (PBC) is an update of the PBC guidelines published in 2009. The 2018 updated Guidance on PBC includes updates on etiol-ogy and diagnosis, role of imaging, clinical manifesta-tions, and treatment of PBC since 2009. The AASLD 2018 PBC Guidance provides a data-supported approach to screening, diagnosis, and clinical man-agement of patients with PBC.

an autoimmune disease because of its hallmark sero-logic signature, antimitochondrial antibody (AMA), and specific bile duct pathology.(1-4) The etiology of PBC is thought to be due to a combination of genetic risk factors and environmental triggers.(5-7) AMA is a highly disease-specific autoantibody(8)

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