Transcription of PRINCIPLES OF POPULATION GENETICS - sinauer.com
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PRINCIPLES OF POPULATION GENETICS - sinauer.com
Daniel L. Hartl & Andrew G. ClarkPRINCIPLES OF POPULATIONGENETICSFOURTH EDITIOND aniel L. HartlHarvard UniversityAndrew G. ClarkCornell UniversitySinauer Associates, Inc. PublishersSunderland, MassachusettsH-C 4E FM 12/4/06 11:56 AM Page iii Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured or disseminated in any form without express written permission from the RELEVANCE PHENOTYPICVARIATION INNATURALPOPULATIONS5 Continuous Variation: The Normal Distribution 5 Mean and Variance 6 The Central Limit Theorem 8 Discrete Mendelian Variation MAINTENANCE MOLECULARPOPULATIONGENETICS15 Electrophoresis 16 Allele Frequencies and Genotype Frequencies 18 Polymorphism and Heterozygosity 20 Allozyme Polymorphisms 21 Inferences from Allozyme Polymorphisms POLYMORPHISMS INDNA SEQUENCES25 Restriction Enzymes 25 The Polymerase Chain Reaction 28 Single Nucleotide Polymorphisms 32 Synonymous and Nonsynonymous Polymorphisms 32 Segregating Sites and Nucleotide Mismatches UTILITY OFGENETICPOLYMORPHISMS38 PREFACExii1 genetic ANDPHENOTYPICVARIATION3H-C 4E FM 12/4/06 11:56 AM Page vi Sinauer Associates, Inc.
Daniel L. Hartl & Andrew G. Clark PRINCIPLES OF POPULATION GENETICS FOURTH EDITION Daniel L. Hartl Harvard University Andrew G. Clark Cornell University
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