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~臨床開発担当者のための PRO ... - jpma.or.jp

Patient Reported Outcomes PRO 7 Ve r 1 . 0 2016 6 .. 1 1 PRO .. 2 PRO .. 2 PRO .. 3 .. 5 2 FDA PRO .. 7 PRO CONCEPTUAL FRAMEWORK .. 7 CONTENT VALIDITY .. 8 PRO .. 9 3 PRO .. 11 .. 11 PRO .. 12 PRO .. 12 PRO .. 13 .. 20 4 PRO .. 23 .. 23 .. 24 .. 25 .. 26 .. 28 .. 29 1) PRO .. 29 2) .. 32 3) 34 4) PRO .. 36 5) PRO .. 36 6) PRO .. 38 7) .. 38 8) .. 40 .. 43 .. 46 1 Patient Reported Outcome PRO HR-QOL Health related quality of life 2015 7 2015 8 7 PRO

DAS28 : Disease Activity Score 28, SGRQ : St George’s Respiratory Questionnaire, AQLQ : Asthma Quality of Life Questionnaire, HADS : Hospital Anxiety and Depression scale, BDI : Beck Depression Inventory, SDISS : Sheehan Disability Scale

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