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PRODUCT MONOGRAPH

PRODUCT MONOGRAPH Pr wellbutrin XL Bupropion Hydrochloride Extended-Release tablets , USP 150 mg and 300 mg Antidepressant Name: Valeant Canada LP Address: 2150 St-Elzear Blvd. West Laval, QC, H7L 4A8 Date of Revision: March 20, 2017 Control Number: 200959 Page 1 of 45 Table of Contents Page PART I: HEALTH PROFESSIONAL INFORMATION .. 2 SUMMARY PRODUCT INFORMATION .. 2 INDICATIONS AND CLINICAL USE .. 2 CONTRAINDICATIONS .. 3 WARNINGS AND PRECAUTIONS .. 3 ADVERSE REACTIONS .. 9 DRUG INTERACTIONS .. 19 DOSAGE AND ADMINISTRATION .. 22 OVERDOSAGE .. 24 ACTION AND CLINICAL PHARMACOLOGY .. 25 STORAGE AND STABILITY .. 28 DOSAGE FORMS COMPOSITION AND PACKAGING .. 28 PART II: SCIENTIFIC INFORMATION .. 30 PHARMACEUTICAL INFORMATION .. 30 CLINICAL TRIALS .. 31 DETAILED PHARMACOLOGY.

Pr WELLBUTRIN XL Bupropion Hydrochloride Extended-Release Tablets, USP 150 mg and 300 mg Antidepressant Name: Valeant Canada LP Address: 2150 St-Elzear Blvd. West Laval, QC, H7L 4A8 Date of Revision: March 20, 2017 Control Number: 200959

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