Transcription of PRODUCT MONOGRAPH FLECAINIDE - AA Pharma
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PRODUCT MONOGRAPH FLECAINIDE - AA Pharma
PRODUCT MONOGRAPH FLECAINIDE FLECAINIDE Acetate Tablets USP 50 mg and 100 mg ANTIARRHYTHMIC AGENT AA Pharma INC. DATE OF REVISION: 1165 Creditstone Road, Unit #1 July 1, 2010 Vaughan, Ontario L4K 4N7 - 1 - PRODUCT MONOGRAPH FLECAINIDE FLECAINIDE Acetate Tablets USP 50 mg and 100 mg THERAPEUTIC CLASSIFICATION Antiarrhythmic Agent ACTIONS AND CLINICAL PHARMACOLOGY FLECAINIDE belongs to the membrane stabilizing group of antiarrhythmic agents; it has electrophysiologic effects characteristics of the 1C class of the modified Vaughan-Williams classification. It also possesses local anesthetic properties. In single cell preparations from canine cardiac tissues (Purkinje fibers), FLECAINIDE decreased the rate of rise (Vmax, Phase 0) of the action potential without greatly affecting its duration; the duration of the effective refractory period was lengthened and a small change was observed in the slope of Phase 4 depolarization.
PRODUCT MONOGRAPH FLECAINIDE Flecainide Acetate Tablets USP 50 mg and 100 mg ANTIARRHYTHMIC AGENT AA PHARMA INC. DATE OF REVISION: 1165 …
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