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Propensity Score Methods Using SAS - BASUG - …
Propensity Score Methods Using Propensity Score Methods Using SASSAS R. Scott Leslie, MPHR. Scott Leslie, MPHMedImpact Healthcare Systems, Healthcare Systems, Diego, CASan Diego, ResearchObservational ResearchKey strength: estimate effect of exposures or Key strength: estimate effect of exposures or treatment in treatment in real worldreal world conditionsconditionsAdvantagesAdvantages Data readily available, inexpensiveData readily available, inexpensive Generate quick resultsGenerate quick results Results more generalizable than controlled trialsResults more generalizable than controlled trials Offer solution to limitations of RCTO ffer solution to limitations of RCTE thicsEthicsFeasibilityFeasibility--Costs /resourcesCosts/resourcesTimeTime--resul ts lagresults lagHawthorne effectHawthorne effectExternal validityExternal validity--patient mixpatient mixSmall samplesSmall samplesObservational ResearchObservational ResearchKey limitation.
Bias in Observational Studies Is outcome due to treatment? Or other factors? Limited by bias – Selection bias – Confounding – Reverse causality
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Meta-analysis of Observational Studies in, Meta-analysis of Observational Studies in Epidemiology, Observational, Observational studies, Of Antiretroviral Drugs for Postexposure, Studies, Extremely low-frequency electromagnetic, EPIDEMIOLOGY Extremely low-frequency electromagnetic, 11. Multicausality: Confounding