Transcription of PROTEIN-PROTEIN INTERACTIONS, VISCOSITY AND …
{{id}} {{{paragraph}}}
Example: tourism industry
PROTEIN-PROTEIN INTERACTIONS, VISCOSITY AND …
PROTEIN-PROTEIN interactions , VISCOSITY AND injectability IN MULTI protein CO-FORMULATIONS- bevacizumab AND rALBUMINSECOND GENERATION ALBUMIN FUSIONSJens T. Bukrinsky, PhDSenior formulation ScientistAt Novozymes Biopharma A/SCambridge October 20132 AGENDACase study on aggregation prevention Analytical challenges and preliminary data Mechanism SAXS DLS AF4 Viscosity3 HUMAN SERUM ALBUMIN - PROPERTIES Structure 585 amino acids, Single chain Three domains 17 disulfide bridges Cys34 is unpaired One tryptophan 66472 g/mol Hydrophobic patches/cavities IpH = Soluble up to >400 g/L Approximately 50 g/L in blood High physical stability Long plasma life 19-20 days Inert SafeLocation of long chain fatty acid binding sitesCurry et al.
protein-protein interactions, viscosity and injectability in multi protein co-formulations-bevacizumab and ralbumin second generation albumin fusions
Loading..
Tags:
Information
Domain:
Source:
Link to this page:
Please notify us if you found a problem with this document: