Randomized Controlled Trials (Experimental Studies)

ERIC at the UNC CH Department of Epidemiology Medical Center Randomized Controlled Trials ( experimental studies ) E R I C N O T E B O O K S E R I E S What are Randomized Trials ? Randomized Trials are epidemiological studies in which a direct comparison is made between two or more treatment groups, one of which serves as a control for the other. Study subjects are randomly allocated into the differing treatment groups, and all groups are followed over time to observe the effect of the different treatments. The control group may either be untreated (placebo- Controlled ) or undergo a gold standard established regimen against which the new regimen will be assessed (active- Controlled ).

treatment and control groups. Types of randomized trials The two general types of randomized trials are clinical trials and community trials, with randomized clinical trials being by far the more common. A randomized clinical trial is an experiment with patients as subjects. The goal is to find an effective treatment for a disease or to evaluate an

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