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Randomized Controlled Trials (Experimental Studies)

ERIC at the UNC CH Department of Epidemiology Medical Center Randomized Controlled Trials ( experimental studies ) E R I C N O T E B O O K S E R I E S What are Randomized Trials ? Randomized Trials are epidemiological studies in which a direct comparison is made between two or more treatment groups, one of which serves as a control for the other. Study subjects are randomly allocated into the differing treatment groups, and all groups are followed over time to observe the effect of the different treatments. The control group may either be untreated (placebo- Controlled ) or undergo a gold standard established regimen against which the new regimen will be assessed (active- Controlled ).

intervention to prevent the progression of a disease. ... of treatment status, the trial is called single-blinded. When both the participants and the investigators are ... Analyzing the results without regard to subject compliance (called "intention-to-treat" analysis)

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