Reduce friability and improve tablet performance during ...

Issue 20: SEP 2010 Reduce friability and improve tablet performance during stability studies with a combination of Fujicalin and Neusilin Greetings! Making high quality tablets of acetaminophen can be a big challenge due to its high cohesive property. during mixing, acetaminophen tends to segregate easily causing problems of low content uniformity. Choosing an excipient which has high flowability, high compressibility, high tablet hardness, low friability with appropriate bulk density is an efficient strategy to solve the problem.

Tablet properties and dissolution profiles are shown in Table 2. All formulations showed very good tablet properties with friability under 0.1%, and tablet hardness above 50 N.

Loading..

Tags:

  Performance, Improves, During, Tablets, Friability, Friability and improve tablet performance during

Information

Related search queries