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Reference ID: 3662552

HIGHLIGHTS OF PRESCRIBING INFORMATION. --------------------------------Contrain dications----------------------------- . These highlights do not include all the information needed to use ADCETRIS safely and effectively. See full prescribing information for Concomitant use with bleomycin due to pulmonary toxicity (4). ADCETRIS. ------------------------------- Warnings and Precautions --------------------------- ADCETRIS (brentuximab vedotin) for injection, for intravenous use Peripheral neuropathy: Monitor patients for neuropathy and institute Initial approval: 2011 dose modifications accordingly ( ). WARNING: PROGRESSIVE MULTIFOCAL Anaphylaxis and infusion reactions: If an infusion reaction occurs, LEUKOENCEPHALOPATHY (PML) interrupt the infusion. If anaphylaxis occurs, immediately See full prescribing information for complete boxed warning. discontinue the infusion ( ). Hematologic toxicities: Monitor complete blood counts prior to each JC virus infection resulting in PML and death can occur in patients dose of ADCETRIS.

dose modifications accordingly (5.1). • Anaphylaxis and infusion reactions: If an infusion reaction occurs, interrupt the infusion. If anaphylaxis occurs, immediately

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Transcription of Reference ID: 3662552

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