Regimen R-CEOP Therapeutic Intent

Page 1 of 3 Regimen R-CEOP Indication diffuse large B Cell lymphoma with contraindications to anthracyclines Therapeutic Intent Radical/Curative Day Medication Dose Route Administration Details 1 Rituximab 375mg/m2 IV Add to sodium chloride See local protocol or product SPC for information of rate of infusion 1 Vincristine IV Max dose 2mg. 50ml sodium chloride minibag over 5-10 minutes. 1 Etoposide 50mg/m2 IV 500ml to 1000ml sodium chloride over 1-2 hours 1 Cyclophosphamide 750mg/m2 IV Slow IV bolus injection or add to sodium chloride and give over 30 minutes. 2 and 3 Etoposide 100mg/m2 PO Take on an empty stomach. Round dose to the nearest 50mg. 1 to 5 Prednisolone 100mg or PO As a single dose with food in the morning. Day 1 may be given prior to the Rituximab infusion as part of the pre-med Cycle Frequency Every 21 days for 3-6 cycles depending on stage of disease Tests required prior to initiation of course FBC, U&E, LFT, Bone profile, glucose, LDH, B2M, serum Igs, hep B screen, electrophoresis.

Page 1 of 3 Regimen R-CEOP . Indication . Diffuse Large B Cell Lymphoma with contraindications to anthracyclines

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  Large, Intent, Therapeutic, Cells, Lymphoma, Diffuse large b cell lymphoma, Diffuse, Therapeutic intent

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