Transcription of Relationships between Lipophilicity and Solubility
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Relationships between Lipophilicity and Solubility
Relationships between Lipophilicity and SolubilityKarl J. Box Physical Chemistry Symposium Nov 29th 2006 Sirius Analytical Instruments Limited/ 342 Copyright Sirius Analytical Instruments Ltd. 2006 LogS vs CLogP-7-6-5-4-3-2-1-1012345 CLogPLogSSolubility versus calculated lipophilicityPresented by James Blake, Array BioPharma Finding Drugs within Chemistry Space / 343 Copyright Sirius Analytical Instruments Ltd. 2006 Log(Intrinsic Solubility ) vs LogPy = - = PLog SMeasured Solubility versus Measured Lipophilicity40 out of 78 compounds within 1 log unit of best fit line = 51%/ 344 Copyright Sirius Analytical Instruments Ltd. 2006 Log(Intrinsic Solubility ) vs LogPy = - = PLog SMeasured Solubility versus Measured Lipophilicity59 out of 78 compounds within log units of best fit line = 76%LogS = - 345 Copyright Sirius Analytical Instruments Ltd.
Relationships between Lipophilicity and Solubility Karl J. Box Physical Chemistry Symposium Nov 29th 2006 Sirius Analytical Instruments Limited
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