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Research OriginalInvestigation ...

Copyright 2016 American Medical Association. All rights of Clinical Criteria for SepsisFor the Third International Consensus Definitionsfor sepsis and Septic Shock ( sepsis -3)Christopher W. Seymour, MD, MSc; Vincent X. Liu, MD, MSc; Theodore J. Iwashyna, MD, PhD; Frank M. Brunkhorst, MD; Thomas D. Rea, MD, MPH;Andr Scherag, PhD; Gordon Rubenfeld, MD, MSc; Jeremy M. Kahn, MD, MSc; Manu Shankar-Hari, MD, MSc; Mervyn Singer, MD, FRCP;Clifford S. Deutschman, MD, MS; Gabriel J. Escobar, MD; Derek C. Angus, MD, MPHIMPORTANCEThe Third International Consensus Definitions Task Force defined sepsisas life-threatening organ dysfunction due to a dysregulated host response to infection. The performance of clinical criteria for this sepsis definition is evaluate the validity of clinical criteria to identify patients with suspectedinfection who are at risk of , SETTINGS, AND POPULATIONA mong million electronic health record encountersfrom January 1, 2010, to December 31, 2012, at 12 hospitals in southwestern Pennsylvania, weidentified those with suspected infection in whom to compare criteria.

Georgia;TomvanderPoll,MD,Academisch MedischCentrum,Amsterdam,theNetherlands; sepsis.....

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