Transcription of Rosiglitazone Abrogates Bleomycin-Induced …
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Rosiglitazone Abrogates Bleomycin-Induced …
Matrix PathobiologyRosiglitazone Abrogates bleomycin -InducedScleroderma and Blocks profibrotic ResponsesThrough peroxisome proliferator -ActivatedReceptor- Minghua Wu, Denisa S. Melichian, Eric Chang,Matthew Warner-Blankenship, Asish K. Ghosh,and John VargaFrom the Section of Rheumatology, Northwestern UniversityFeinberg School of Medicine, Chicago, IllinoisThe nuclear hormone receptor, peroxisome prolif-erator-activated receptor (PPAR)- , originally iden-tified as a key mediator of adipogenesis, is ex-pressed widely and implicated in diverse natural and synthetic agonists ofPPAR- abrogated the stimulation of collagen synthe-sis and myofibroblast differentiation induced bytransforming growth factor (TGF)- in vitro. To char-acterize the role of PPAR- in the fibrotic processinvivo, the synthetic agonist Rosiglitazone was used in amouse model of scleroderma .
Matrix Pathobiology Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated
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