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Safety of Fipronil in Dogs and Cats: a review of literature

Safety of Fipronil in Dogs and Cats : a review of literature Conducted on behalf of the Australian Pesticides and Veterinary Medicines Authority (APVMA) Fipronil Animal Safety review Page 2 of 21 Table of Contents 1 Introduction .. 3 2 Methodology of assessment .. 3 3 Mechanism of action .. 4 4 Metabolism of Fipronil .. 4 5 Published studies investigating the efficacy of Fipronil -containing products .. 5 6 Adverse drug experience reports for Fipronil in dogs and cats .. 6 ADEs in Australia .. 6 Off label use of Fipronil .. 7 Efficacy issues .. 8 ADEs in USA .. 8 Global ADE reports.

agencies, including the World Health Organisation (WHO) and the US Environmental Protection Agency (EPA). 3 Mechanism of action Fipronil exhibits high insecticidal activity against many insects and other arthropod pests (Tingle et al., 2003). The principle mechanism of action is against the γ-aminobutyric acid (GABA) receptor-chloride complex.

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