Sample size calculation in epidemiological studies

Gerontologija 2006; 7(4): 225 231 GERONTOLOGIJAT heory and practiceSample size calculation in epidemiological studiesV. Kasiulevi ius1, V. apoka1, R. Filipavi i t 21 Vilnius University 2 Institute of Experimental and Clinical Medicine at Vilnius UniversitySummarySample- size determination is often an important step in planning an epidemiological study. There are several approaches to determining Sample size . It depends on the type of the study. Descriptive, observational and randomized controlled studies have different formulas to calculate Sample size . In this article, we discuss the formulas that can help to estimate Sample size in an epidemiological trial. We present a few examples from clinical practice, which may contribute to the understanding of this : Sample size determinationDetermining an appropriate Sample size for a clinical trial is an essential step in the statistical design of the pro-ject. An adequate Sample size helps ensure that the stu-dy will yield reliable information, regardless of whether the ultimate data suggest a clinically important difference between the treatments being studied, or the study is in-tended to measure the accuracy of a diagnostic test or the incidence of a disease.

Sample size calculation in epidemiological studies 227 where N is the size of the population and n is the size of the sample. If fpc is close to 1, then there is almost no ef-

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