Transcription of SCIENTIFIC DISCUSSION 1. Introduction
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SCIENTIFIC DISCUSSION 1. Introduction
EMEA 2007 1/52 SCIENTIFIC DISCUSSION 1. Introduction Chronic myelogenous leukaemia (CML) is one of several chronic myeloproliferative diseases, a family of clonal disorders of pluripotential hematopoetic stem cells in the marrow. CML has a yearly incidence of 1 in 100 000 in Western countries and its frequency increases steadily with age (Greer JP 2004). It is uncommon in children and accounts for less than 5 % of all childhood leukemias (Rowe and Lichtman 1984). In the population, men are affected more than women (3:2) (Moloney 1977). A reciprocal chromosome translocation t(9;22), in which the ABL proto-oncogene on chromosome 9 is translocated near the BCR gene on chromosome 22, is the main cause of CML.
©EMEA 2007 1/52 SCIENTIFIC DISCUSSION 1. Introduction Chronic myelogenous leukaemia (CML) is one of several chronic myeloproliferative diseases, a
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