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SECTION Protein Structure and Function I

27 ISECTIONP rotein Structure and FunctionCHAPTER 2 Protein StructureCHAPTER 3 Protein 272/15/11 7:50 AM Jones & Bartlett Learning, LLC. NOT FOR SALE OR DISTRIBUTION 28 2 Protein StructureOUTLINE OF The -Amino Acids -Amino acids have an amino group and a carboxyl group attached to a central carbon acids are represented by three-letter and one-letter The Peptide Bond -Amino acids are linked by peptide Protein PurificationProtein mixtures can be fractionated by and other charged biological polymers migrate in an electric Primary Structure of ProteinsThe amino acid sequence or primary Structure of a purified Protein can be sequences can be obtained from nucleic acid BLAST program compares a new polypeptide sequence with all sequences stored in a data with just one polypeptide chain have primary, secondary, and tertiary structures while those with two or more chains also have quaternary Weak Noncovalent BondsThe polypeptide folding pattern is determined by weak non-covalent Secondary StructuresThe -helix is a compact Structure that is stabilized by hydrogen -conformation is also stabilized by hydrogen and turns connect different peptide segments, allowing polypeptide chains to fold back on combinations of secondary structures, called supersecondary structures or folding motifs, appear in many different cannot yet

CHAPTER 2 Protein Structure 29 A s described in Chapter 1, the Watson-Crick Model helped to bridge a major gap between genetics and biochemistry, and in …

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