Transcription of Simplified Biorelevant Media for Screening Dissolution ...
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Simplified Biorelevant Media for Screening Dissolution ...
Simplified Biorelevant Media for Screening Dissolution Performance of Poorly Soluble Drugs e-mail: Thomas Zoeller and Sandra Klein1. Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, 9 Max von Laue Street, Frankfurt am Main 60438, Germany INTRODUCTION Middlesbrough, England); Tween 40 (polyoxyethylene S. imulation of gastrointestinal conditions is essential to sorbitan monopalmitate), sample # SURF7168 (ICI. adequately predict the in vivo behavior of poorly surfactants, Middlesbrough, England); Tween 60. soluble drugs. Simulating small intestinal conditions (polyoxyethylene sorbitan monostearate), with Biorelevant Media such as fasted state simulated lot # S753320040 (Cognis GmbH, Duesseldorf, Germany);. intestinal fluid (FaSSIF) and fed state simulated intestinal Tween 80 (polyoxyethylene sorbitan monooleate), fluid (FeSSIF) has become standard practice in many lot # 813530 (Th. Goldschmidt, Essen, Germany); and Dissolution laboratories (1 6).
8 Dissolution Technologies | NOVEMBER 2007 INTRODUCTIONS imulation of gastrointestinal conditions is essential to adequately predict the in vivo behavior of …
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