Transcription of Slow-Stirring Method for Highly Hydrophobic …
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validation study Slow-Stirring Method for POW-determination 1 Ring TestProposal of the Netherlands for a new OECD guidelinePartition Coefficient n-Octanol/Water (POW) Slow-Stirring Method for Highly Hydrophobic ChemicalsValidation ReportRIVM contract-Nrs602730M/602700/01 Johannes TollsIRAS Environmental Toxicology and ChemistryUtrecht UniversityValidation study Slow-Stirring Method for POW-determination 2 Table of contentsThe validation 3 Annex 1 The validation management 9 Parties and 9 Persons 10 Annex 2 Original guideline proposal - Draft submitted to 11 Annex 3 - The validation study 25 Annex 4 Test compound selection and establishing reference 27 Number of test 27 Test compound 28 Derivation of log POW,ref 29 Annex 5 - Guideline for participants in the validation 31I. General:.. :.. 31 Annex 6 - Results of the validation 37 Corollary 38 Overview of the 39 Repeatability and reproducibility of the Slow-Stirring 46 Conclusions and 48 Annex 7 Error analysis / Method 49 Error 49 Optimization of Technical Guideline 51 Recommendations for validation study of optimized Technical Guideline 51 Derivation of log POW,ref for 2,2 ,3,3 5,5 ,6,6 52 Annex 8 Results of the validation study with the optimized 54 Data 54 Overview of the log POW 55 Statistical 57
Validation study ‘Slow-stirring method for POW-determination’ 3 The validation study This document describes the validation procedure in …
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