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Solid Dispersions: An Overview To Modify Bioavailability ...
International Journal of PharmTech ResearchCODEN (USA): IJPRIF ISSN : 0974-4304 , , pp 1338-1349, Oct-Dec 2009 Solid Dispersions: An Overview To ModifyBioavailability Of Poorly Water Soluble DrugsRuchi Tiwari1*, Gaurav Tiwari1, Birendra Srivastava2 and Awani K. Rai11 Pranveer Singh Institute of Technology, Dept. of Pharmaceutics, Kalpi Road, Bhauti,Kanpur-208020, Uttar Pradesh, India2 Jaipur National University, Jagatpura, Jaipur, Rajasthan, IndiaINTRODUCTIONAn ideal drug delivery system should be able to deliveran adequate amount of drug, preferably for an extendedperiod of time for its optimum therapeutic activity. Mostdrugs are inherently not long lasting in the body andrequire multiple daily dosing to achieve the desired bloodconcentration to produce therapeutic activity.
Gaurav Tiwari et al/Int.J. PharmTech Res.2009,1(4) 1341 in solid dispersions can absorb moisture, which may result in phase separation, crystal growth or conversion …
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