Transcription of Solubility and dissolution - Pharmaceutical Press
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Solubility and dissolution - Pharmaceutical Press
Learning objectivesUpon completion of this chapter, you should be able to answer the following questions: What is a solution? What is the difference between Solubility and dissolution ? What variables control a solute s Solubility ? What variables control dissolution ? What do Solubility and dissolution have to do with each other?3 Solubility and dissolutionSolubility, dissolution , and dissolution rateSolubility and dissolution are different concepts, but are related. Solubility is the capacity of a solute to dissolve in a pure solvent. This means the maximum amount of solute that the pure solvent can hold in solution, at specified environmental conditions. Beyond this saturation concentration, a solute cannot further dissolve in the amount of solvent provided. It can exist tenuously in a supersaturated con dition, but will eventually revert to the solvent s true capacity.
crystallization Figure 3.2. Dissolution equilibrium. If the solvent sufficiently interacts with solvent particles, the solute inter mingles with the solvent. The crystalline structure of the solute is reduced and separated by the solvent into individual ions, atoms or molecules. This process can be visualized in Figure 3.3. Key Point
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