Standardizationoffoodchallengesinpatientswithimmediate ...

Review articleStandardization of food challenges in patients with immediatereactions to foods position paper from the European Academyof Allergology and Clinical ImmunologyAt present, the double blind placebo controlled foodchallenge (DBPCFC) represents the only way to establishor rule out an adverse reaction to a food in older childrenand adults, whereas an open challenge controlled bytrained personnel is sufficient in infants and youngchildren (1). The challenge procedure is not, however,C. Bindslev-Jensen1, B. K. Ballmer-Weber2, U. Bengtsson3, C. Blanco4,C. Ebner5, J. Hourihane6,A. C. Knulst7, D. A. Moneret-Vautrin8,K. Nekam9, B. Niggemann10,M. Osterballe1, C. Ortolani11,J. Ring12, C. Schnopp13, T. Werfel141 Allergy Center, Odense University Hospital,Odense, Denmark;2 Allergy Unit, Department ofDermatology, University Hospital Zurich, Zurich,Switzerland;3 The Asthma and Allergy ResearchGroup, Department of Respiratory, Medicine andAllergy, Sahlgrenska University Hospital,Gothenburg, Sweden;4 Secci*n de Alergia,Hospital Dr Negr,n, Las Palmas de , Spain;5 Allergieambulatorium, Wien, Austria;6 WellcomeTrust Clinical Research Facility, SouthamptonUniversity Hospitals NH STrust, Southampton, UK;7 Department of Dermatology/Allergology, UniversityM

made to the statistical evaluation when investigating patientswithcontroversialsymptoms. In classical type I allergy reacting with objectively measurable signs (e.g. a drop in FEV

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