Transcription of Statins: mechanism of action and effects
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Statins: mechanism of action and effects
Vol 5, No 4, 2001 pp. 378-387. Review statins : mechanism of action and effects Camelia Stancu, Anca Sima *. "Nicolae Simionescu" Institute of Cellular Biology and Pathology, Bucharest, Romania Received: November 12, 2001; Accepted: December 5, 2001. Introduction effects on Classification of statins - cholesterol esterification and - How they are obtained its accumulation in macrophages - Liver metabolism - endothelial cell function - Physico-chemical properties - inflammatory process - Specific activity - proliferation, migration and Mechanisms for the action of statins apoptosis of arterial smooth muscle cells - Mechanisms involving lipids - stability of the atherosclerotic plaque - Mechanisms involving intracellular - platelets activation signaling pathways - coagulation process Beneficial effects of statins
lipoproteins) [9]. All statins reduce LDL cholesterol non-liniarly, dose-dependent, and after administration of a single daily dose [5]. Efficacy on triglyceride reduction parallels LDL cholesterol reduction [10]. Direct effects of HMG CoA reductase inhibition Statins inhibit hepatic syntesis of apolipoprotein B-
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