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Statistics: An introduction to sample size calculations

statistics : An introduction to sample size calculationsRosie Cornish. IntroductionOne crucial aspect of study design is deciding how big your sample should be. If you increaseyour sample size you increase the precision of your estimates, which means that, for any givenestimate / size of effect, the greater the sample size the more statistically significant theresult will be. In other words, if an investigation is too small then it will not detect resultsthat are in fact important. Conversely, if a very large sample is used, even tiny deviations fromthe null hypothesis will be statistically significant, even if these are not, in fact, practicallyimportant. In practice, this means that before carrying out any investigation you should havean idea of what kind of change from the null hypothesis would be regarded as practicallyimportant. The smaller the difference you regard as important to detect, the greater thesample size such as time, cost, and how many subjects are actually available are constraints thatoften have to be taken account of when designing a study, but these should not dictate thesample size there is no point in carrying out a study that is too small, only to come up withresults that are inconclusive, since you will then need to carry out another study to confirm orrefute your initial are two approaches to sample size calculations : Pr

Statistics: An introduction to sample size calculations Rosie Cornish. 2006. 1 Introduction One crucial aspect of study design is …

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