Steroidogenic Pathways - GDX

3 HSD3 HSD17,20 Lyase17,20 LyaseCYP2117-hydroxylase17-hydroxylaseCY P21 CYP11b15 5 5 11 HSD3 HSD3 HSDCOMTCOMT17 HSD3A41A15 3 HSD17 HSD1B117 HSD5 5 17 HSDA romatase (CYP19)Aromatase (CYP19)11-DeoxycortisolCorticosteronePre gnanediolPregnanetriola-THFTHFTHE2-MeO(E 1+E2)2-OH(E1+E2)16a-OHE14-OH(E1+E2)4-MeO (E1+E2)EtiocholanoloneAndrosteroneAndros tanediolCholesterolPregnenoloneProgester one17-OH-Progesterone17-OH-PregnenoloneA ndrostenedioneDHEAA ndrostenediolEstrone (E1)Estriol (E3)Estradiol (E2)DHTT estosteroneCortisol(active)(inactive)Cor tisoneCongenital adrenal hyperplasia (CAH), smoking, E2, progesterone, azole antifungals, spironolactoneCrucifers, berries, I3C, DIM, soy, flaxseed, caffeine, rosemary, exercise, thyroxineExcess sugar or n6 fats, cimetidine, OCPsHypothyroidism, pesticide exposure, smoking, caffeine, various medicationsGrapefruit, peppermint oil, rosemary, wild yam, anti-fungals & other medicationsCeliac disease, 5 -reductase inhibitors ( , finasteride, saw palmetto, pygeum, stinging nettle), flaxseed, soy isoflavones, EGCG, quercetin, progesterone, some progestinsInsulin resistance, obesity,PCOS, androgenic alopecia,essential HT, high-carb diet,sodium restriction, DHEAH yperglycemia, hyperinsulinemia, PCOS (ovary), stress, alcohol, antiepilepticsCAH, chronic ETOH ingestion, PCBtoxici

3 β HSD 3 β HSD 17,20 Lyase 17,20 Lyase CYP2 1 17-hydroxylase 17-hydroxylase CYP2 1 CYP11b 1 5 α β 5 β 11βHSD 3 β HS D COMT COMT 17βHSD 3A 4 1 A 1 5 α 3 α HS D 17βHSD 1B1 17βHSD 5 β 5 α 17βHSD Aromatase (CYP19)

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