Transcription of SUGI 27: Generating Randomization Schedules Using SAS(r ...
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SUGI 27: Generating Randomization Schedules Using SAS(r ...
Paper 267-27 Generating Randomization Schedules Using SAS ProgrammingChunqin Deng and Julia Graz, PPD, Inc., Research Triangle Park, North CarolinaABSTRACTR andomization as a method of experimental control hasbeen extensively used in clinical trials. Generating therandomization schedule has been an essential part ofsome trials. We discuss how to use SAS programmingand SAS PROC PLAN to generate the randomizationschedule. The issues related to Randomization are alsodiscussed. Case studies are used to illustrate the use ofSAS programming and SAS PROC PLAN in generatingrandomization : Randomization Schedule, Clinical Trial,PROC PLANINTRODUCTIONR andomization as a method of experimental control hasbeen extensively used in clinical trials. The fundamentaloccasion for Randomization is the assignment oftreatment conditions to patients or, as preferred herein,assignment of patients to treatment tends to produce treatment groups inwhich the distributions of prognostic factors, known andunknown, are similar.
The PLAN procedure constructs designs and randomizes plans for factorial experiments, specifically nested and crossed experiments and randomized block designs. PROC PLAN can also be used for generating lists of permutations and combinations of numbers. The PLAN procedure can construct the following types of experimental designs:
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