Transcription of SUGI 27: Generating Randomization Schedules Using SAS(r ...
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SUGI 27: Generating Randomization Schedules Using SAS(r ...
Paper 267-27 Generating Randomization Schedules Using SAS ProgrammingChunqin Deng and Julia Graz, PPD, Inc., Research Triangle Park, North CarolinaABSTRACTR andomization as a method of experimental control hasbeen extensively used in clinical trials. Generating therandomization schedule has been an essential part ofsome trials. We discuss how to use SAS programmingand SAS PROC PLAN to generate the randomizationschedule. The issues related to Randomization are alsodiscussed. Case studies are used to illustrate the use ofSAS programming and SAS PROC PLAN in generatingrandomization : Randomization Schedule, Clinical Trial,PROC PLANINTRODUCTIONR andomization as a method of experimental control hasbeen extensively used in clinical trials. The fundamentaloccasion for Randomization is the assignment oftreatment conditions to patients or, as preferred herein,assignment of patients to treatment tends to produce treatment groups inwhich the distributions of prognostic factors, known andunknown, are similar.
Parallel designs are often used in phase II – phase IV clinical trials to compare the efficacy of a new drug to an active control group or placebo group. In our example, we assume that we need to generate a randomization schedule for a study with three arms (a new drug treatment, an active control treatment, and a placebo group).
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