Tablets & Capsules September 2013 …

IAs appeared in Tablets & Capsules September tablet defectsMatthew KnoppEditorTablet defects bedevil many manufacturers. This article outlinessome strategies that tablet production experts use to resolve themost common ones, including weight variation, black spots,capping, and sticking and the condition of the tablet press (settings, worncomponents) and changes to raw materials (particle sizeand shape, segregation, moisture). Changes in the envi-ronmental temperature and humidity can also have aneffect. At the press, weight variation can stem from anumber of causes, including improper feeder or compres-sion settings; worn punches, die pockets, or punchguides; and temperature changes during a May, about 90 people gathered in Cleveland to gaininsight on tablet defects from a panel of experts.

Natoli said it’s normal for powders, over time, to abrade the tooling and other areas they contact, but only rarely—usually because of a poor choice of steel—is the

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