Transcription of Tablets & Capsules September 2013 …
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Tablets & Capsules September 2013 …
IAs appeared in Tablets & Capsules September tablet defectsMatthew KnoppEditorTablet defects bedevil many manufacturers. This article outlinessome strategies that tablet production experts use to resolve themost common ones, including weight variation, black spots,capping, and sticking and the condition of the tablet press (settings, worncomponents) and changes to raw materials (particle sizeand shape, segregation, moisture). Changes in the envi-ronmental temperature and humidity can also have aneffect. At the press, weight variation can stem from anumber of causes, including improper feeder or compres-sion settings; worn punches, die pockets, or punchguides; and temperature changes during a May, about 90 people gathered in Cleveland to gaininsight on tablet defects from a panel of experts. Led byMike Tousey of Techceuticals, the panel included JimMossop, project manager at Fette Compacting America;Ed Godek, manager of process technology at Glatt AirTechniques; Fabrianno Ferrini, product manager at IMAN orth America; Fred Murray, president of Korsch America;and Dale Natoli, president of Natoli most common defects include variations in weightand potency, black spots, capping, and sticking and pick-ing.
Tablet weight and the feeder assembly Weights can vary if the paddle feeder overworks the powder and changes its characteristics, Mossop said. His
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