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TACO vs. TRALI - SEABB

taco vs . TRALI :Recognition, Differentiation, and Investigation of Pulmonary Transfusion ReactionsShealynn Harris, Assistant Medical DirectorAmerican Red Cross Blood ServicesSouthern RegionCase Presentation 74 year-old female with GI bleed Transfused 1 unit Apheresis Platelets 4 units RBCs During transfusion Difficulty breathing Hypoxia Increased respiratory rateConsiderations: Transfusion Reaction Pulmonary Transfusion Reaction Transfusion-associated circulatory overload (TACO) Transfusion-related acute lung injury ( TRALI ) Transfusion Reaction with Pulmonary Symptoms Allergic (anaphylaxis) Septic Transfusion ReactionOther Considerations Myocardial infarction Acute respiratory distress syndrome (ARDS) Sepsis Drug reaction PneumoniaChallenges in CharacterizingPulmonary Symptoms Associated with Transfusion Recognizing a transfusion reaction Differentiating between possible etiologies Criteria for diagnosis Diagnostic tools Contributing factors ( , underlying disease) Obtaining complete clinical and laboratory information Investigating donors and understanding results of investigationCase Presentation 74 year-old female with GI bleed Transfused 1 unit Apheresis Platelets 4 units RBCs During transfusion Difficulty breathing Hypoxia Increased respiratory ratePre-TransfusionKopkoPM, Holland PV.

TACO vs. TRALI: Recognition, Differentiation, and Investigation of Pulmonary Transfusion Reactions Shealynn Harris, M.D. Assistant Medical Director

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