Transcription of Temperature Dependence of IP3-Mediated Local and Global ...
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Temperature Dependence of IP3-Mediated Local and Global Ca2 DSignalsGeorge D. Dickinson * and Ian Parker Department of Neurobiology and Behavior and Department of Physiology and Biophysics, University of California, Irvine, CaliforniaABSTRACT We examined the effect of Temperature (12 40 C) on Local and Global Ca2 signals mediated by inositol trisphos-phate receptor/channels (IP3R) in human neuroblastoma (SH-SY5Y) cells. The amplitudes and spatial spread of Local signalsarising from single IP3R (blips) and clusters of IP3R (puffs) showed little Temperature Dependence , whereas their kinetics (dura-tions and latencies) were markedly accelerated by increasing Temperature . In contrast, the amplitude of Global Ca2 wavesincreased appreciably at lower temperatures , probably as a result of the longer duration of IP3R channel opening. Severalparameters, including puff and blip durations, puff latency and frequency, and frequency of repetitive Ca2 waves, showeda biphasic Temperature Dependence on Arrhenius plots.
Temperature Dependence of IP 3-Mediated Local and Global Ca 2D Signals George D. Dickinson†* and Ian Parker†‡ †Department of Neurobiology and Behavior and ‡Department of Physiology and Biophysics, University of California, Irvine, California ABSTRACT We examined the effect of temperature (12–40 C) on local and global Ca2þ signals mediated by inositol trisphos-
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