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TERATOGENS AND THEIR EFFECTS

23-1 Wendy Chung, : 851-5313e-mail: congenital malformation is an anatomical or structural abnormality present at birth. Congenitalmalformations may be caused by genetic factors or environmental insults or a combination of thetwo that occur during prenatal development . Most common congenital malformations demonstratemultifactorial inheritance with a threshold effect and are determined by a combination of genetic andenvironmental factors. During the first two weeks of gestation, teratogenic agents usually kill theembryo rather than cause congenital malformations.

pictured below (Fig. 23-2). For instance, the critical period for brain growth and development is from three to 16 weeks. However the brain’s differentiation continues to extend into infancy. Terato-gens can produce mental retardation during both embryonic and fetal periods (Fig. 23-2).

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