THE COMPLEMENT SYSTEM - Jiwaji University
COMPLEMENT PLAYS A KEY ROLE IN BOTH INNATE AND ADAPTIVE IMMUNITY The complement system is the major effector of the humoral immune system. Although the discovery of complement and most early studies were linked to the activity of
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JIWAJI UNIVERSITY, GWALIOR
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JIWAJI UNIVERSITY, GWALIOR
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mmc.gov.bdThe Alternative Complement Pathway • Activation of the alternative complement pathway begins when C3b (or C3i) binds to the cell wall and other surface components of microbes . C3b can also bind to IgG antibodies. Factor B then combines with the cell -bound C3b to form C3bB. Factor D then splits the bound Factor B into Bb and Ba, forming C3bBb .
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