Transcription of The Gelsinger Case - UAB
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The Gelsinger Case - UAB
Robert Stein brook The Gelsinger case background The death of Jesse Gelsinger in September 1999 is one of the defining cases in the recent history of research with humans. Gelsinger , 18, died during a gene transfer experiment at the University of Pennsylvania School of Medicine.! His death~the first directly attributed to gene transfer-raised profound ques-tions about the protection of patients in this high-profile research field, as well as in other clinical studies. It also raised questions about adherence to research protocols, the reporting of adverse events, informed consent, and financial conflicts of interest. It shook the confidence of the public and the federal government in the competence and ethics of clinical researchers and the institu-tions where they work, and led to efforts to improve the protection of research participants.
Background The death of Jesse Gelsinger in September 1999 is one of the ... the investment in the field by the National Institutes of Health (NIH) advocated caution: "Significant problems remain in all basic ... this enzyme deficiency are rare-affecting 1 in 40,000 to I
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