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THE INTERNET STROKE CENTER

THE INTERNET STROKE CENTERPRESENTATIONS AND DISCUSSIONS ON STROKE MANAGEMENTA ntithrombotic Therapy & STROKE ProphylaxisBrian F. Gage, , MScDepartment of Internal MedicineWashington University School of MedicineBarnes-Jewish Hospital Blood Thinner ServiceTABLE OF CONTENTS Anticoagulants for STROKE Prophylaxis 2 Warfarin 3 Clotting Cascade 4 Risk Factors for Hemorrhage During Warfarin Therapy 6 Relationship of Protime Ratio to International Normalized Ratio (INR) 72 Prevention: After a Prior Cardio-Embolic STROKE 82 Prevention: STROKE Prevention in Reversible Ischemia Trial (SPIRIT) 9 Atrial Fibrillation: Results of RCT s, Warf. vs. No Rx 10 Atrial Fibrillation: Results of RCT s, No Rx vs. ASA 11 Atrial Fibrillation: STROKE Rate with Warfarin and Antiplatlet Therapy 12 Atrial Fibrillation: Findings of RCTs 13 INR-Speci!c Incidence Rate of Adverse Event 14 Lowest Effective Intensity for Warfarin Therapy for STROKE Prevention in Atrial Fibrillation 15 Days Since Index Hospitalization 16 Recommendations for Atrial Fibrillation 17 Mechanical Valves: Effect of INR on Incidence of Adverse Events 18 Effect of ASA on Adverse Events in Patients with Mechanical Valves who are Receiving Warfarin 19 Recommendations for Mechanical Valves 20 Effect of ASA on Adverse Events in Patients Post-MI (Antiplatelet Trialists' Collaboration) 21 Effect of Nicoumalone or Phenprocoumon

THE INTERNET STROKE CENTER PRESENTATIONS AND DISCUSSIONS ON STROKE MANAGEMENT Antithrombotic Therapy & Stroke Prophylaxis Brian F. Gage, M.D., MSc

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