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THE INTERNET STROKE CENTER

THE INTERNET STROKE CENTERPRESENTATIONS AND DISCUSSIONS ON STROKE MANAGEMENTA nticoagulation in Acute Ischemic StrokeWilliam J. Powers, of Neurology and RadiologyWashington University School of MedicineStroke CENTER at Barnes-Jewish HospitalTABLE OF CONTENTS An Introduction to Heparin 2 Clinical Trials of Anticoagulation in STROKE 4 Additional Studies 6 Additional Studies and Conclusions 8 References 1An Introduction to HeparinWhat is Heparin? Heterogeneous collection of straight chain anionic sulfated mucopolysaccharides usually obtained from animal lung or intestine Potentiates activity of antithrombin III - an endogenous inhibitor of coagulation factors IIa, IXa and Xa Binds to platelets and plasma proteinsHeparinoids and Low Molecular Weight HeparinseparinPharmacological Reduced anti-IIa effect, primary effect on Xa Reduced platelet interaction Reduced plasma protein bindingClinical Assay activity as anti-Xa

THE INTERNET STROKE CENTER PRESENTATIONS AND DISCUSSIONS ON STROKE MANAGEMENT Anticoagulation in Acute Ischemic Stroke William J. Powers, M.D. Departments of Neurology and Radiology

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