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The Intraclass Correlation Coefficient (ICC)

Prepared by: Elizabeth DeLong and Yuliya Lokhnygina Reviewed by: NIH Collaboratory Biostatistics/Study design Core Version: , last updated June 26, 2014 Page | 1 The Intraclass Correlation Coefficient (ICC) A working document from the NIH Collaboratory Biostatistics/Study design Core. This work was supported by a cooperative agreement (U54 AT007748) from the NIH Common Fund for the NIH Health Care Systems Research Collaboratory. The views presented here are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Background The Intraclass Correlation Coefficient (ICC), related to the design effect (DEFF) [1] as: DEFF=1+(n 1)ICC is a key parameter in the design and analysis of group- or cluster-randomized trials (GRTs or CRTs).

Jun 26, 2014 · Methods for obtaining estimates of the ICC Multiple methods of estimating ICC have been described in the literature [9,10]. Properties of different estimators depend on study characteristics such as the balance of the design, the number and size of clusters, and the presence of covariates. In the case of binary data, the

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