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THE LUGANO CLASSIFICATION

THE LUGANO CLASSIFICATIONRECOMMENDATIONS FOR HODGKIN S AND NON-HODGKIN SLYMPHOMA: STAGING, RESPONSE ASSESSMENT AND FOLLOW UPEmanuele Zucca, MDFrancesca Pavanello, MDOncology Institute of Southern Switzerland (IOSI)RECOMMENDATIONS:INITIAL EVALUATIONBACKGROUND2011 workshop at 11-ICML 2007 IWG revised guidelines1999 NCI criteria2014 LUGANO Classification1971 Ann Arbor Classification1988 Cotswolds modification2013 2ndworkshop at 12-ICMLB arrington SF, et 2014;32(27):3048-58 -Cheson BD, et al. JCO 2014;32(27):3059-68 SF BarringtonNG MikhaeelL KostakogluM MeignanM HutchingsS M ellerLH SchwartzE ZuccaRI FisherJ TrotmanOS HoekstraRJ HicksMJ O DohertyR HustinxA BiggiBD ChesonBD ChesonRI FisherSF BarringtonF CavalliLH SchwartzE ZuccaTA Lister11-ICML & 12-ICML WORKSHOPS Recommendations for initial evaluation, and response assessment

BONE MARROW EVALUATION • HL If PET-CT is performed, bone marrow biopsy no longer indicated for HL • DLBCL Biopsy if the PET is negative and identifying a discordant histology is important for patient management • Other subtypes ~2.5 cm unilateral bone marrow biopsy is recommended, along with immunohistochemistry and flow cytometry at

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