Transcription of The Mechanism of Action of Isothiazolone Biocides
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The Mechanism of Action of Isothiazolone Biocides
Terry M. WilliamsABSTRACTI sothiazolone Biocides have proven efficacy and per-formance for microbial control in a variety of industrialwater treatment applications. Understanding themechanism of Action of industrial Biocides is importantin optimizing their use and combating resistance ifencountered. Isothiazolones utilize a two-step mecha-nism involving rapid inhibition (minutes) of growth andmetabolism, followed by irreversible cell damageresulting in loss of viability (hours). Cells are inhibitedby disruption of the metabolic pathways involvingdehydrogenase enzymes. Critical physiological func-tions are rapidly inhibited in microbes, includinggrowth, respiration (oxygen consumption), and energygeneration (adenosine triphosphate synthesis).
The Mechanism of Action of Isothiazolone Biocides PowerPlant Chemistry 2007, 9(1) 15 tion in propylene glycol and was included for comparison. All biocide concentrations in …
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