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The Moderately Efficient Enzyme: Evolutionary and ...
Published:April 20, 2011r2011 American Chemical |Biochemistry2011, 50, 4402 4410 CURRENT Moderately Efficient Enzyme: Evolutionary and PhysicochemicalTrends Shaping Enzyme ParametersArren Bar-Even, Elad Noor, Yonatan Savir, Wolfram Liebermeister, Dan Davidi, Dan S. Tawfik, andRon Milo*, Department of Plant Sciences, Department of Physics of Complex Systems, and Department of Biological Chemistry, The WeizmannInstitute of Science, Rehovot 76100, IsraelbSSupporting InformationNatural selection shapes the regulation of metabolic enzymesenforcing precise spatial and temporal control. It also plays acentral role in the evolution of enzymatic kinetic parameters,including the turnover number (kcat) and the apparent bindingconstants of substrates (KM), as both these parameters, togetherwith enzyme concentrations, affect metabolism and growth literature usually highlights kinetically supreme enzymessuch as triosephosphate isomerase, commonly termed a perfectenzyme .1,2 What, however, are the kinetic parameters of the average enzyme ?
4403 dx.doi.org/10.1021/bi2002289 | Biochemistry2011, 50, 4402 4410 Biochemistry CURRENT TOPIC phase and a water phase. This indicator of hydrophobicity was found to ...
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