Transcription of THE Rh BLOOD GROUP SYSTEM - Lippincott …
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THE Rh BLOOD GROUP SYSTEM - Lippincott …
139 CHAPTER10139 THE Rh BLOOD GROUP SYSTEMCONNIE WESTHOFFThe Rh BLOOD GROUP SYSTEM is one of the mostpolymorphic and antigenic BLOOD GROUP sys-tems. It is second only to ABO in importance inblood transfusion and is well known as a primarycause of hemolytic disease of the fetus and newborn(HDFN). The principal antigen is D, and the termsRh positiveand Rh negativerefer to the presence orabsence of D antigen. Caucasians of European ex-traction have the highest incidence of the Rh-nega-tive phenotype (15% to 17%), and Rh-negative typeis much less common in Africa (5%) and Australiaand is considered a rare BLOOD type not routinelytested for in some parts of Asia ( 1%). Other com-mon Rh antigens include the antithetical C and c,and E and e antigens.
(Fig. 10-1). The RhD and RhCE proteins encoded by the two genes differ by 32 to 35 amino acids. This contrasts with most blood group system antigens that
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