Transcription of The Use of Transmembrane pH Gradient-Driven …
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JOURNAL OF LIPOSOME RESEARCH, 4(1), 529-553 (1994) THE USE OF Transmembrane PH Gradient-Driven drug encapsulation IN THE PHARMACODYNAMIC evaluation OF LlpoSOMAL DOXORUBICIN Lawrence D. Mayer", Pieter R. Cullis2 and Marcel B. Bally' 'The British Columbia Cancer Agemy, Division of Medical Oncology, 600 West 10'" Ave., Vancouver, V5Z 4E6 Canada 'The University of British Columbia., Department of Biochemistry, 2146 Health Sciences Mall, Vancouver, V6T 123 Canada ABSTRACT The toxicity and efficacy properties of doxorubicin entrapped inside liposomes are sensitive to the physical characteristics of the vesicle carrier system. Studies addressing such relationships must use preparation procedures with the ability to independently vary vesicle size, lipid composition and drug to lipid ratio while maintaining high trapping efficiencies.
journal of liposome research, 4(1), 529-553 (1994) the use of transmembrane ph gradient-driven drug encapsulation in the pharmacodynamic evaluation of …
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