Transcription of Therapeutic Class Overview Benign Prostatic Hyperplasia ...
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Therapeutic Class Overview Benign Prostatic Hyperplasia ...
Page 1 o f 6 Copyright 2014 Review Completed on 09/ 22/2014 Therapeutic Class Overview Benign Prostatic Hyperplasia Treatments Therapeutic Class Overview /Summary: The agents approved for the treatment of signs and symptoms of benignprostatic Hyperplasia will be the focus of this review. The -adrenergic blockers including, alfuzosin,doxazosin, silodosin, tamsulosin, and terazosin, reduce smooth-muscle tone in the prostate andbladder neck decreasing lower urinary tract symptoms (LUTS) secondary to BPH.
• FDA-approval of silodosin was based on two clinical trials where it was compared to placebo and demonstrated its efficacy in decreasing the International Prostate Symptom Score (IPSS) and
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