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Types of mutations and their impact on protein functionToday s lecture :Mutations can be classified by their effect on the DNA sequence OR the encoded protein1 From my lecture 4 (10/1):Classification of mutations by their effects on the DNA molecule Substitution: base is replaced by one of the other three bases Deletion: block of one or more DNA pairs is lost Insertion: block of one or more DNA pairs is added Inversion: 180 rotation of piece of DNA Reciprocal translocation: parts of nonhomologous chromosomes change places Chromosomal rearrangements: affect many genes at one time2 The triplet nature of the genetic code means that base changes within coding sequence can have several different genetic codeI am not going to discuss the experiments that led to the deciphering of the genetic code.

RNA polymerase where to start and stop (transcription initiation and termination signals). B. In eukaryotes, there is additional information that tells the splicing machinery where to cut and paste. 11. ... Defective Fibrillin-1 proteins disrupt the integrity of the chains.

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mcb.berkeley.edu

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mcb.berkeley.edu

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mcb.berkeley.edu

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mcb.berkeley.edu

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mcb.berkeley.edu

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mcb.berkeley.edu

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www.agilent.com

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www.agilent.com

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assets.thermofisher.com

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files.zymoresearch.com

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