Toward Biorelevant Dissolution: Application of a Biphasic ...

dissolution Technologies | FEBRUARY 201225e-mail: Biorelevant dissolution : Application of a Biphasic dissolution Model as a Discriminating Tool for HPMC Matrices Containing a Model BCS Class II DrugDaniel J. Phillips1, Samuel R. Pygall2, V. Brett Cooper2, and James C. Mann2,*1 Department of Chemistry, University of Warwick, Coventry, Warwickshire, CV4 7AL, UK2 Development Laboratories, MSD Development Laboratories, Hertford Road, Hoddesdon, Herts, EN11 9BU, UKABSTRACTThe potential of a Biphasic dissolution system to assist with the analysis of controlled-release (CR), Biopharmaceutics Classification System (BCS) Class II pharmaceutical products has been investigated.

26 Dissolution Technologies | FEBRUARY 2012 cloud points, which was further related to an increase in polymer solubility. Alternatively, Saito (27) and Daly et al. (28) demonstrated that the addition of SDS to HPMC-based matrices increased the solution viscosity and

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