Transcription of TOXICITY SUMMARY FOR MANGANESE - hydratechnm.org
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TOXICITY SUMMARY FOR MANGANESE - hydratechnm.org
TOXICITY SUMMARY FOR MANGANESE July 1995 Prepared by: A. A. Francis and C. Forsyth Chemical Hazard Evaluation Group Biomedical and Environmental Information Analysis Section Health Sciences Research Division Oak Ridge National Laboratory* Oak Ridge, Tennessee Prepared for: OAK RIDGE RESERVATION ENVIRONMENTAL RESTORATION PROGRAM *Managed by Lockheed Martin Energy Systems, Inc., for the Department of Energy under Contract No. DE-AC05-84OR21400 iv EXECUTIVE SUMMARY MANGANESE is an essential trace element in humans that can elicit a variety of serious toxic responses upon prolonged exposure to elevated concentrations either orally or by inhalation. The central nervous system is the primary target. Initial symptoms are headache, insomnia, disorientation, anxiety, lethargy, and memory loss.
A reference concentration (RfC) of 0.05 g/m3 (EPA 1995) for chronic inhalation exposure was μ calculated from a human LOAEL of 0.05 mg/m3 for impairment of neurobehavioral function from an epidemiological study by Roels et al. (1992). The study population was occupationally exposed to
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